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KMID : 0615720160330020097
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Jouranl of Korean Acupuncture and Moxibustion society
2016 Volume.33 No. 2 p.97 ~ p.108
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Analgesic Effect of Styrax Japonica Pharmacopuncture on Formalin-Induced Pain in Rats
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Park Mu-Seob
Lee Hyun-Jong
Lee Yun-Kyu
Kim Mi-Rye
Park Hae-Jin
Kim Jae-Soo
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Abstract
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Objectives: This study was performed to investigate the analgesic effect of Styrax japonica pharmacopuncture on formalin induced pain in rats and to figure out efficient extraction method.
Methods: The subjects were divided into 5 groups; normal group(treated with normal saline at KI03, and injected normal saline at right hindpaw after 35 minutes), control group(treated with normal saline at KI03, and injected with formalin at right hindpaw after 35 minutes), water group(treated by hot water extraction pharmacopuncture at KI03, and injected with formalin at right hindpaw after 35 minutes), ethanol group(treated with ethanol extraction pharmacopuncture at KI03, and injected with formalin at right hindpaw after 35 minutes), and ultrasound group(treated with ultrasound extraction pharmacacupuncture and injected with fromalin formalin at right hindpaw after 35 minutes). We conducted a formalin test with ultrasonic vocalization(USV), and after the test checked for substance P, Aspartate aminotransferase(AST), and Alanine aminotransferase(ALT) concentration in the blood for each of the groups.
Results: There was a significant analgesic effect of Styrax japonica pharmacopuncture in the early phase of the formalin test, and pharmacopuncture made with an ultrasound extracting method was observed to have a better analgesic effect than other extracting methods in early phases. The substance P concentration decreased significantly in the Styrax japonica pharmacopuncture treated group and no difference was found in the AST and ALT concentration of each group.
Conclusion: These results demonstrated that Styrax japonica pharmacopuncture had analgesic effects in noxious nociceptors stimulation. Also pharmacopuncture made with an ultrasound extracting method had a better analgesic effect than others.
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KEYWORD
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Styrax japonica, Pharmacopuncture, Analgesic, Formalin Test, Taegye(KI03)
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